Endocrine Abstracts

Proinsulin makes three evolutionarily-conserved disulfide bonds, two of which connect the insulin B and A chains, and one intrachain bond within the A chain. In Type II diabetes mellitus, increasing evidence suggests that insulin-secreting pancreatic β cells show signs of endoplasmic reticulum (ER) stress and an increase in the presence of proinsulin with mispaired disulfide bonds. In addition, heterozygous expression of misfolded mutant proinsulin is known to cause autos...

Hyperuricemia, results from the disorder of purine metabolism or endocrine system, leads to an inflammatory arthritis and gout. Sesame oil has been reported to have a potent anti-inflammatory effect in various animal models. The aim of the present study is to examine the therapeutic effect of sesame oil on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in air pouch in unanaesthetised Sprague–Dawley rats. Air pouch, a commonly used model for gouty ar...